Natural firing patterns reduce sensitivity of synaptic plasticity to spike-timing
نویسندگان
چکیده
منابع مشابه
Determinants of Spike Timing-Dependent Synaptic Plasticity
Recent studies show that the precise timing of presynaptic inputs and postsynaptic action potentials influences the strength and sign of synaptic plasticity. In this issue of Neuron, Sjöström and colleagues (2001) determine how this so-called spike timing-dependent plasticity depends on the frequency and strength of the presynaptic inputs.
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Spike synchronization is thought to have a constructive role for feature integration, attention, associative learning, and the formation of bidirectionally connected Hebbian cell assemblies. By contrast, theoretical studies on spike-timing-dependent plasticity (STDP) report an inherently decoupling influence of spike synchronization on synaptic connections of coactivated neurons. For example, b...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2013
ISSN: 1471-2202
DOI: 10.1186/1471-2202-14-s1-p304